The cashmere goat is a type of livestock primarily known for its cashmere. Cashmere is a vital raw material in the textile industry, possessing significant economic value. The embryonic stage is the main stage of the formation of hair follicle structures, which directly influence both the yield and quality of cashmere. LncRNA, which lacks protein-coding ability and exceeds 200 nucleotides in length, has been discovered to play a role in hair follicle development. In this study, we screened and identified the lncRNA MSTRG.14227.1, which is associated with the morphogenesis of secondary hair follicles. This lncRNA can inhibit the proliferation and migration of dermal fibroblasts through the chi-miR-433/ADAMTS3 axis, ultimately suppressing the development of secondary hair follicles.

Read the full article in the Journal of Animal Science.