August 14, 2025

Interpretive Summary: Relative bioavailability of 25-hydroxycholecalciferol vs. cholecalciferol and vitamin D3 requirements in White Pekin ducks from 15 to 42 d of age

Interpretive Summary: Relative bioavailability of 25-hydroxycholecalciferol vs. cholecalciferol and vitamin D3 requirements in White Pekin ducks from 15 to 42 d of age

By: Lei Zhuang, Yating Li, Yongyan Jin, Li Chen, Kexin Gao, Shuaiqin Wang, Jindang Cao, Mingkai Wang, Zhengkui Zhou, Ming Xie, Shuisheng Hou, Jing Tang

Vitamin D3 (VD3) is essential for calcium and phosphorus absorption and bone development. However, endogenous synthesis of VD3 in poultry is insufficient to meet growth requirements, necessitating dietary supplementation. NRC (1994) recommended VD3 requirements for both starter and growing White Pekin ducks were 400 IU/kg. With the increasing growth rate of meat ducks, NRC recommendations may be inadequate for the growth of modern meat ducks. Our previous results have shown VD3 requirements for starter male White Pekin ducks were 233 to 633 IU/kg, but the requirements for growing Pekin ducks remain unclear. 25-Hydroxycholecalciferol (25-OH-D3) is the main circulating form of VD3 in the blood, is more readily utilized than VD3. However, its bioavailability in growing Pekin ducks remains unexamined. This study aimed to determine VD3 and 25-OH-D3 requirements in growing male White Pekin ducks and relative bioavailability of these 2 compounds. The results showed that VD3 and 25-OH-D3 requirements for growing Pekin ducks were 698 IU/kg and 352 IU/kg, respectively. The relative bioavailability of 25-OH-D3 compared to VD3 was 188%, based on slope-ratio comparisons from multiple linear regressions of plasma 25-OH-D3 concentrations.

Read the full article in the Journal of Animal Science.