September 04, 2025

Interpretive Summary: Increasing dietary soybean-derived trypsin inhibitor protein compromises nursery pig performance, nitrogen digestibility, and retention

Interpretive Summary: Increasing dietary soybean-derived trypsin inhibitor protein compromises nursery pig performance, nitrogen digestibility, and retention

By: Mitchell J Nisley, Kayla A Miller, Joel D Spencer, Omarh F Mendoza, Hari B Krishnan, Nicholas K Gabler

Trypsin inhibitor proteins are intrinsic to soybeans and soy products, presenting an omnipresent antinutritional factor challenging soy-based product use in swine diets. Increasing dietary trypsin inhibitor (TIU/mg) protein linearly compromises growth performance, feed efficiency, and nitrogen retention as soybean TIU increased in the diet of nursery pigs. These performance outcomes were caused by reductions in nitrogen digestibility and retention. Altogether, trypsin inhibitor protein concentration should be monitored in soybean protein-containing feed and feed ingredients when fed to nursery pigs.

Read the full article in the Journal of Animal Science.