Interpretive Summary: Culturomic-, metagenomic-, and transcriptomic-based characterization of commensal lactic acid bacteria isolated from domestic dogs using Caenorhabditis elegans as a model for aging

By: An Na Kang, Daye Mun, Sangdon Ryu, Jeong Jae Lee, Sejong Oh, Min Kyu Kim, Minho Song, Sangnam Oh, Younghoon Kim

In tandem with the fast expansion of the pet-economy industry, the present aging research has been noticing the function of probiotics in extending the healthy lifetime of domestic animals. In this study, collaborating with understanding the characteristics of gut microbiome from canine feces by multiomics approaches including culturomics, metagenomics, and transcriptomics, we isolate and identify commensal lactic acid bacteria (LAB) as novel potential probiotics for the use of antiaging using Caenorhabditis elegans surrogate animal model and multiomics analysis. The selected commensal LAB could be provided beneficial effects in the aging of domestic animals by modulating the dynamics of gut microbiome and applied in the future companion animal market by clarifying their purpose and function.