Interpretive Summary: An in silico study of derivative of Newcastle disease virus epitopes based vaccine against hemagglutunin neuraminidase protein
By: Farrukh Jamil, Laiba Aslam, Laraib, Hira Ali, Kainaat Shoukat, Muhammad Asif Rasheed, Sohail Raza, Muhammad Ibrahim
Newcastle disease is a viral disease that causes severe problems in poultry birds. The disease is lethal with a high influence and death rate. Many vaccines have been developed against the Newcastle disease virus (NDV). An NDV epitope-based vaccine was previously reported by our laboratory. In this study, we studied 5,040 chimera of the last NDV-reported vaccine construct. Analysis of the chimeric data highlighted a chimera appears to be more non-allergic and antigenic compared to our last reported vaccine construct. The vaccine may induce stronger immunity in the birds. We have checked the results of the vaccine by using computer software and programs. New vaccine was generated by epitopes shuffling in the previous multi-epitope vaccine (MEV). Our new vaccine construct contains 259 amino acids and is immunogenic, more antigenic, and non-allergen. Our study suggests that our new MEV is more effective and stable protein against NDV strains.
Read the full article in the Journal of Animal Science.