Interpretive Summary: Changes in gut microbiota and short-chain fatty acids are involved in the process of canine obesity after neutering
By: Kang Yang, Xinye Lin, Shiyan Jian, Jiawei Wen, Xiaoying Jian, Shansong He, Chaoyu Wen, Tingting Liu, Xin Qi, Yulong Yin, Baichuan Deng
Neutering contributes to canine obesity risk. In this study, obesity rate of 60% at 21 mo after neutering was observed. Obese dogs had greater serum triglyceride, total cholesterol, high-density lipoprotein cholesterol, and leptin levels and lower adiponectin level than ideal weight dogs. In addition, fecal microbiota analysis found a decreasing microbial diversity in obese dogs, and decreasing SCFAs-producing bacteria Megamonas, Bacteroides, and Prevotella_9 in obese dogs resulted in lower production of fecal acetate, propionate, and butyrate. Importantly, strong negative correlations between SCFAs-producing bacteria and body weight, TG, and HDL-C revealed that SCFAs-producing bacteria are involved in the process of canine obesity after neutering. Thus, intervention with SCFAs-producing bacteria may be a target for the prevention or treatment of canine obesity after neutering. Moreover, weight control before neutering may also contribute to the prevention of canine obesity after neutering.
Read the full article in the Journal of Animal Science.