June 13, 2024

Interpretive Summary: Bta-miR-181d and Bta-miR-196a mediated proliferation, differentiation, and apoptosis in Bovine Myogenic Cells

Interpretive Summary: Bta-miR-181d and Bta-miR-196a mediated proliferation, differentiation, and apoptosis in Bovine Myogenic Cells

By: Liang Chengcheng, Sayed Haidar Abbas Raza, Yang Zhimei, Wang Sihu, Yu Shengchen, Bandar Hamad Aloufi, Li Bingzhi, Linsen Zan

In this research, we explored the functions of two specific microRNAs, bta-miR-181d and bta-miR-196a, in the muscle cells of Qinchuan cattle. These tiny molecules are known to play crucial roles in various cellular processes. Our findings reveal that these microRNAs significantly influence cell growth, death, and differentiation in muscle cells through their interactions with the AKT and MAPK signaling pathways. This study not only expands our understanding of the miR-181 and miR-196 families but also sheds light on the broader role of microRNAs in the development and growth of skeletal muscles. These insights could have important implications for animal husbandry and the study of muscle biology.

Read the full article in the Journal of Animal Science.