January 02, 2025

Interpretive Summary: Cannabidiol can affect morphology, morphometry, enzymatic and microbial activity of rabbit digestive system

Interpretive Summary: Cannabidiol can affect morphology, morphometry, enzymatic and microbial activity of rabbit digestive system

By: Nadia Musco, Giulia Pascon, Nicola Francesco Addeo, Matteo Zarantoniello, Mariarosaria Lanzieri, Ike Olivotto, Francesca Tulli, Valeria Iervolino, Ruggero Amato, Pietro Lombardi, Fulvia Bovera

The study compares the characteristics of the small and large intestines in 2 groups of healthy meat rabbit feeding or not with a cannabidiol extract for 27 d. Feed intake and final weight are similar for both groups. However, cannabidiol significantly interfered with protein digestion in the small intestine and decreased the microbial activity in the cecum. These results suggest that cannabidiol is able to affect the physiological activity of both the small and large intestines in rabbits. For that reason, further research is necessary to clarify the impact of cannabidiol on the gastrointestinal tract of rabbits and its long-term use may require the monitoring of intestinal function.

Read the full article in the Journal of Animal Science.