Reactive oxygen species (ROS) are byproducts of energy production that have the potential to detrimentally interact with cellular components, creating damage or dysfunction within the body. In small quantities, ROS are important signaling molecules, essential for stimulating adaptation to stimuli such as inflammation and exercise. However, when ROS production exceeds that of antioxidants, neutralizing agents of ROS, negative consequences such as inflammation may result. To combat this, antioxidants are prophylactically supplemented in various forms with herbal formulated blends becoming a growing field of interest. To evaluate the antioxidant and anti-inflammatory potential of Protandim Nrf2 Synergizer, an herbal blend containing milk thistle, bacopa, ashwagandha, green tea, and turmeric, four concentrations were provided to mature, sedentary horses for 56 d. Blood caffeine concentrations increased in a dose-dependent manner but remained below the acceptable concentration for competition horses within the United States, allowing its potential use in equine athletes. No other differences were observed at the Protandim concentrations tested but further research evaluating an increased dosage or to horses experiencing elevated stress is warranted.

Read the full article in the Journal of Animal Science.